GENETIC POLYMORPHISMS OF HLA-G GENE IN RHEUMATOID ARTHRITIS
نویسندگان
چکیده
This study was aimed to evaluate the influence of Human Leukocyte Antigens- G (HLA-G) gene polymorphisms on risk rheumatoid arthritis (RA). In present study, blood samples were collected from 100 patients and healthy controls. Serum levels HLA-G in both controls measured using ELISA kit which shown a higher significant differences (p< 0.05) comparison between them (539.3 ng/ml 139.3ng/ml) respectively. The frequency allele genotypes patient groups control determined Polymerase Chain Reaction (PCR) for 14 bp polymorhisms exon 8 (rs66554220) while direct sequencing analysis done determine 2 (rs1130355) (G 1850 A) SNPs human leucocyte antigens- (HLA- G). There statistically difference all HLA-G14-bp RA with probability homozygote genotype insertion (0.006), deletion (0.003) heterozygote (0.000) From results odd ratio (OR) found that existence homozygotes give protection effect disease O.R= 0.44 heterozygotes act as factor 3.31. Homozygotes had no because not groups. mutation occur position G>A three (GG, AG AA). Calculations showed GG AA associated p- value genotypes. While association p (0.449).From gave O.R( 0.29 0.76 ) respectively, acted 4.0.
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ژورنال
عنوان ژورنال: The Iraqi Journal of Agricultural science
سال: 2023
ISSN: ['2410-0862', '0075-0530']
DOI: https://doi.org/10.36103/ijas.v54i2.1712